Cisplatin Ototoxicity Mechanism

The molecular mechanism of cisplatin related ototoxicity and destruction of the outer hair cells is currently unknown. it is thought to involve the production and . Cisplatin interaction clinical management; nephrotoxic drugs (e. g. aminoglycosides, amphotericin, cisplatin, contrast dye, frusemide, nsaids) additive nephrotoxicity: avoid combination or monitor renal function closely: ototoxic drugs (e. g. aminoglycosides, frusemide, nsaids) additive ototoxicity: avoid combination or perform regular. 3 cisplatin acts in the tumour cell through mechanisms such as dna damage and production of reactive oxygen species, which lead to cell death by apoptosis. cell death can also occur via necrosis when the cell is exposed to high concentrations of cisplatin. 1. Aug 24, 2020 the prevalence of hearing loss following cisplatin treatment is the mechanisms underlying cisplatin‐mediated ototoxicity is of major health .

Feb 17, 2021 · vancomycin is a medication used in the treatment of serious gram-positive bacterial infections. it is in the cell wall synthesis inhibitor class of antimicrobial medications. this activity reviews the indications, action, and contraindications for vancomycin as a valuable antimicrobial in the treatment of gram-positive bacterial infections. this activity will highlight the mechanism of action. Mechanisms of cisplatin ototoxicity: theoretical review. gonçalves ms (1), silveira af, teixeira ar, hyppolito ma. introduction: cisplatin is an effective chemotherapeutic agent commonly used in the cisplatin ototoxicity mechanism treatment of malignant tumours, but ototoxicity is a significant side effect. objectives: to discuss the mechanisms of cisplatin ototoxicity and subsequent cell death, and to present the results of experimental studies.

Brasil Otoprotection Mechanisms Against Oxidative Scielo

The exact mechanism of cisplatin ototoxicity is not known. the drug is understood to damage multiple regions of the cochlea, causing the death of outer hair . Cisplatin ototoxicity appears cisplatin ototoxicity mechanism to be triggered by ros that initiate a cascade of molecular events that lead to apoptosis of outer hair cells, resulting in loss of dpoaes and elevation of high frequency thresholds for cap and abr. Results. among the groups exposed to ototoxic doses of cisplatin, there was an increase in glutathione peroxidase immunostaining in two groups, the one . More cisplatin ototoxicity mechanism images.

Cisplatin is a chemotherapy medication used to treat a number of cancers. these include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. it is given by injection into a vein.. common side effects include bone marrow suppression, hearing problems, kidney damage. Jun 12, 2021 · to cisplatin in head and neck cancer cell lines marinela bostan 1,2, ototoxicity, hematologic toxicity, or central nervous system afflictions, that eventually will lead to stopping the treatment [5–7]. better understanding of the action mechanism of cispt and dose efficiency [11,12]. Apr 6, 2021 however, the mechanism of how metformin protects against cisplatin ototoxicity has not been fully explored. according to the rudimentary .

Cisplatininduced Ototoxicity Updates On Molecular

Furosemide Uses Interactions Mechanism Of Action

Identification summary. streptomycin is an aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections.. generic name streptomycin drugbank accession number db01082 background. streptomycin, an antibiotic derived from streptomyces griseus, was the first aminoglycoside to be discovered and used in practice in the. Key words: cisplatin, glutathione, glutathione ester, hearing loss, ototoxicity, outer hair cells if the primary mechanism of d-methionine protection is . Cisplatin: furosemide may increase cisplatin ototoxicity mechanism the nephrotoxic and ototoxic activities of cisplatin. clenbuterol: the risk or severity of hypokalemia can be increased when clenbuterol is combined with furosemide. clevidipine: furosemide may increase the excretion rate of clevidipine which could result in a lower serum level and potentially a reduction in.

Dec 17, 2018 aminoglycosideand cisplatin-induced ototoxicity: mechanisms and ototoxicity refers to damage of inner ear structures (i. e. the cochlea and . Finally, cisplatin-induced dna damage and activation of cisplatin ototoxicity mechanism the apoptotic process could be targeted for cisplatin-induced hearing loss. this review focuses on recent development in our understanding of the mechanisms underlying cisplatin-induced hearing loss and provides examples of how drug therapies have been formulated based on these mechanisms.

Gentamicin, sold under brand name garamycin among others, is an antibiotic used to treat several types of bacterial infections. this may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. it is not effective for gonorrhea or chlamydia infections. it can be given intravenously, by injection into a muscle. Cisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated with cisplatin for injection and may be so severe that drug must be discontinued. Although the etiology of cisplatin-induced ototoxicity remains unclear, an increasing body of evidence suggests that the ototoxicity of cisplatin is mainly related to the production of reactive oxygen species and activation of apoptotic pathway in cochlear tissues.

Jun 28, 2014 · 23 mechanism of action of loop diuretic 24. 24 interactions • concomitant use w/ aminoglycoside or cisplatin increases the risk of nephrotoxicity and ototoxicity • pgs are important in maintaining gf; cisplatin ototoxicity mechanism nsaid reduces the effects of diuretics • probenecid reduces the effects of diuretics by inhibiting its secretion into the lumen. 25. Myelosuppression, nausea and vomiting (30-90%), peripheral neuropathy, ototoxicity, anaphylaxis, acute kidney failure (rare), haemolytic uraemic syndrome (rare) and loss of vision (rare). cisplatin: iv: as above. Oct 27, 2017 cisplatin induces apoptosis of hair cells through activation of mitochondrial pathway which can be targeted to inhibit cell death. another approach . Jan 26, 2018 but cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with .

Mar 9, 2020 a literature review of aminoglycoside and cisplatin ototoxicity. cherrabi kaoutar specific mechanisms, the great semi logical variability, the. Mechanism of ototoxic action of cisplatin recent studies pointed out that the cytostatic/cytotoxic effects of cddp originate from both nuclear and cytoplasmic signaling pathways [ 8 ]. it is known that only ~1% of intracellular cddp forms covalent bonds with nuclear dna [ 9 ], but cddp also exerts prominent cytotoxic effects in enucleated cells (cytoplasts) [ 10 ]. Sep 21, 2016 mean hearing loss after cisplatin treatment was computed for each the molecular mechanism of ototoxicity has not yet been established fully, . Generic name acetylcysteine drugbank accession number db06151 background. acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. 14,15,16,17 acetylcysteine has also been studied for a wide variety of off-label indications with mixed results. 8,9,10. acetylcysteine was granted fda approval on 14 september 1963. 18.